11/25/21 11:30 AM EST
- Chicago at Detroit, 12:30 PM (ET)
Bears: DE Mario Edwards, QB Justin Fields, DT Akiem Hicks, TE Jesper Horsted, WR Allen Robinson, CB Teez Tabor, RB Damien Williams
Lions: WR Trinity Benson, QB David Blough, LB Trey Flowers, OT Matt Nelson, OG Halapoulivaati Vaitai
- Las Vegas at Dallas
Raiders: CB Keisean Nixon, RB Peyton Barber, LB Nick Kwiatkoski, DE Malcolm Koonce, OT Jackson Barton, DT Kendal Vickers
Cowboys: WR CeeDee Lamb, G/C Matt Farniok, QB Will Grier
- Buffalo at New Orleans
Bills: DE Carlos Basham, DT Vernon Butler, S Damar Hamlin, OT Bobby Hart, CB Cam Lewis, WR Isaiah McKenzie, RB Zack Moss
Saints: FB Alex Armah, QB Ian Book, DE Marcus Davenport, RB Mark Ingram, RB Alvin Kamara, DE Tanoh Kpassagnon,OT Ryan Ramczyk
11/28 - 12:05 PM EST
- Atlanta at Jacksonville
Falcons: LB Deion Jones, CB Kendall Sheffield, DL John Cominsky, DL Mike Pennel, DL Jonathan Bullard
Jaguars: CB Shaq Griffin, LB Dakota Allen, OL KC McDermott, TE Jacob Hollister, TE Luke Farrell, DE/LB Jordan Smith
- NY Jets at Houston
Jets: WR Corey Davis, RB La’Mical Perine, OL Isaiah Williams, DL Jonathan Marshall, DL Tim Ward, CB Rachad Wildgoose, S Jarrod Wilson
Texans: TE Jordan Akins, S Justin Reid, DB Cre'Von LeBlanc, TE Jeff Driskel, QB Deshaun Watson, WR Davion Davis
- Tennessee at New England
Titans: OG Nate Davis, LB Rashaan Evans, LB David Long, RB Jeremy McNichols, DL Teair Tart
Patriots: TE Devin Asiasi, OLB Ronnie Perkins, QB Jarrett Stidham, OT Yasir Durant, RB J.J. Taylor
- Philadelphia at NY Giants
Eagles: DT Marlon Tuipulotu, RB Jordan Howard, CB Tay Gowan, CB Kary Vincent, QB Reid Sinnett, CB Mac McCain
Giants: WR Sterling Shepard, TE Kaden Smith, TE Kyle Rudolph, WR Kadarius Toney, FB Cullen Gillaspia, OG Wes Martin
- Pittsburgh at Cincinnati
Steelers: QB Dwayne Haskins, CB Joe Haden, LB Buddy Johnson, TE Kevin Rader, DT Isaiah Buggs
Bengals: WR Auden Tate, WR Trenton Irwin, TE Mitchell Wilcox, OL Fred Johnson, CB Vernon Hargreaves, DT Tyler Shelvin
- Tampa Bay at Indianapolis
Buccaneers: WR Antonio Brown, LG Ali Marpet, QB Kyle Trask, S Andrew Adams, RB Ke'Shawn Vaughn
Colts: R Mike Strachan, RB Marlon Mack, OT Julien Davenport, OL Will Fries, DT Antwaun Woods
- Carolina at Miami
Panthers: WR Terrace Marshall Jr., QB Matt Barkley, S Kenny Robinson, CB Rashaan Melvin, LB Kamal Martin, TE Colin Thompson
Dolphins: TE Adam Shaheen, DB Trill Williams, S Brandon Jones, S Will Parks, LB Darius Hodge, DL John Jenkins
- LA Chargers at Denver
Chargers: OG Matt Feiler, CB Asante Samuel, S Alohi Gilman, QB Easton Stick, RB Larry Rountree, FB Gabe Nabers
Broncos: S Kareem Jackson, OT Bobby Massie, DE Shelby Harris, QB Brett Rypien, S Jamar Johnson, WR Tyrie Cleveland
- Minnesota at San Francisco
Vikings: S Camryn Bynum, OG Wyatt Davis, CB Harrison Hand, QB Kellen Mond, WR Ihmir Smith-Marsette, LB Chazz Surratt
49ers: RB JaMycal Hasty, OL Colton McKivitz, DL Maurice Hurst , DE Jordan Willis
- LA Rams at Green Bay
Rams: OT Tremayne Anchrum, LB Chris Garrett, S JuJu Hughes, OT Alaric Jackson, QB Bryce Perkins, WR Ben Skowronek
Packers: CB Kevin King, DB Vernon Scott, OL David Bakhtiari, WR Malik Taylor, DL Jack Heflin
- Cleveland at Baltimore
Browns: WR Anthony Schwartz, FB Andy Janovich, S Richard LeCounte III, DE Ifeadi Odenigbo, T James Hudson III, WR Rashard Higgins, DT Tommy Togiai
Ravens: DE Calais Campbell, CB Jimmy Smith, CB Chris Westry, WR Miles Boykin, OL Cedric Ogbuehi, TE Josh Oliver
11/29 - 7:05 PM EST
- Seattle at Washington
Seahawks: QB Jacob Eason, RB Travis Homer, OG Damien Lewis, DT Robert Nkemdiche, RB Rashaad Penny, OG Dakoda Shepley, S Nigel Warrior
Washington: CB Corn Elder, WR Antonio Gandy-Golden, C Tyler Larsen, WR Dax Milne, DE Olubunmi Rotimi, TE Ricky Seals-Jones
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