My suggestion is to consider each player's schedule. Not just the season-long schedule, but you might as well analyze their playoff schedule since you plan on being in the playoffs, right?

Below I have done the work for you.

For quarterbacks, running backs and receivers, I have researched the defenses they will go up against this season. Separately, I have analyzed Weeks 15-17. I used last season's defensive numbers because, 1) that's all the data we have to go on until the season begins and 2) most team defenses stay relatively close year-to-year. (Last year's Eagles team being a rare exception).

Quarterbacks

The Arizona Cardinals and Kyler Murray have the "easiest" schedule based on the numbers, both for the overall season and the playoffs (at Houston, Atlanta and at Cincinnati). But for the last three seasons, Murray has been just outside of the top-10 and consistent in his production (21.3 FPts/G, 21.5 and 21.4). It's been since 2021 that Murray was a top-five fantasy quarterback. The offense is essentially the same in 2025 as it was in 2024 with James Conner a year older, but Marvin Harrison Jr. a year wiser. You shouldn't expect much better than the recent past and I make his ceiling the bottom of the top-10.

Everyone loves Josh Allen... me too. But have you seen his fantasy playoff schedule. The league did him no favors scheduling at New England, at Cleveland and versus the defending Super Bowl Champion Eagles (yes, I like saying that, after all I'm a born and raised Philadelphian). Would that sway me to draft Lamar Jackson or Joe Burrow instead? I think yes.

Are you trying to decide between Justin Herbert (ADP 108.7) and Dak Prescott (109.0)? If all things were equal, I would like Prescott throwing to CeeDee Lamb and George Pickens, but they are not equal. Dallas has one of the toughest schedules for a quarterback with the opposing defenses allowing just 19.9 FPts/G, while the Chargers face a middle-of-the-pack lineup. Come playoff time, the difference is enormous, the Chargers have the second-best schedule (22.7 fantasy points allowed) and the Cowboys the third-worst (19.4).

I'm still not a big believer in Sam Darnold after one good season in Minnesota, but the schedule is favorable to the first-year Seattle Seahawk. Jaxon Smith-Njigba and Cooper Kupp are decent, but not Justin Jefferson, Jordan Addison and T.J. Hockenson. The Seahawks will be led by their running game, but come playoff time, Darnold might be useful against Indianapolis, Los Angeles Rams and at Carolina if your starter is Jordan Love, Brock Purdy or Caleb Williams, who have unfavorable schedules.

Running Backs

Next question... Christian McCaffrey (ADP 9.0) or rookie Ashton Jeanty (10.3)? The disparity in schedules makes this an easy pick for me - CMC. In both the regular season and the playoffs, the 49ers' running back has the much easier schedule. As long as McCaffrey begins the season healthy, I know he should produce elite numbers, while Jeanty is still an unknown quantity. (But I'm also not stupid, I'd draft Isaac Guerendo too.)

How about De'Von Achane (ADP 13.0) and Jonathon Taylor (19.7)? The season-long numbers slightly favor the Miami running back, but from Week 15-17, Taylor will have a big advantage. While Achane will be trying to produce at Pittsburgh and against Cincinnati and Tampa Bay, the Colts face Seattle, San Francisco and Jacksonville. Advantage Taylor.

You say you like Omarion Hampton? Yes, he should have a very nice career, but the 2025 schedule doesn't help him. The Chargers have the second-worse running back schedule and worst playoff schedule (at KC, at Dallas, Houston). Near Hampton's 40.3 ADP I can get Kenneth Walker (39.3) who has the fifth-best season-long schedule and second-best playoff schedule. Or perhaps Chuba Hubbard (43.0).

Wide Receivers

Knowing I like the Eagles, you would think I like A.J. Brown (ADP 18.3) over Drake London (20.3), but you would be wrong. London has the more favorable schedule in both the regular season and in the playoffs. Also, neither Darnell Mooney nor Ray-Ray McCloud will threaten London's target share, while DeVonta Smith is always a threat to Brown and I also see Jahan Dotson being more of a regular season factor than last year.

Here are two more wideouts close in ADP, but with one having a distinct advantage. Zay Flowers (ADP 59.0) versus Carolina rookie Tetairoa McMillan (62.7). Flowers produced a 1,059 yards last season and owned the medium depth targets, but this season a healthy Mark Andrews and the addition of DeAndre Hopkins may mean fewer medium-range targets. Add in the 24th-best regular-season schedule and the 30th playoff lineup and I like the rookie's chances both regular season and Weeks 15-17 where the Panthers have top-five schedules.

Finally, for those asking where the tight end analysis is, I did the work, but didn't show it, because the spread from top-to-bottom was too small for significant variance between team schedules.